USB serial loopback on macOS client

On macOS 12, I am seeing an issue related to RequestToSend/ClearToSend (i.e., CTS value does not follow the RTS value) when using RS232 loopback (Prolific USB to Serial adapter) connected via virtualhere client. I am using macOS Monterey on an intel Mac. Could macOS be restricting it? Any idea?

Note:
On Linux/Windows with RS232 loopback connected via VirtualHere client, I am able to set/reset RTS and check CTS follow the RTS value.

For example, I used Python library (pyserial) to reproduce this issue and I see the same issue when using MATLAB serial library also.

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On macOS 12.5, With RS232 loopback connected to VirtualHere - CTS value does not follow the RTS value.
##########

$ /Applications/Python\ 2.7/IDLE.app/Contents/MacOS/Python
Python 2.7.18 (v2.7.18:8d21aa21f2, Apr 19 2020, 20:48:48)
[GCC 4.2.1 Compatible Apple LLVM 6.0 (clang-600.0.57)] on darwin
Type "help", "copyright", "credits" or "license()" for more information.
>>> import serial
>>> import time
>>> s = serial.Serial('/dev/tty.usbserial-8210',9600)
>>> s.getCTS()
False
>>> s.setRTS(True)
>>> s.setRTS(False)
>>> s.setRTS(True)
>>> time.sleep(0.05)
>>> s.getCTS()
False
>>> s.setRTS(True)
>>> time.sleep(0.05)
>>> s.getCTS()
False
>>> s.write('hello')
5
>>> s.read()
'h'
>>> s.read()
'e'
>>> exit()

############
On Debian 10, With RS232 loopback connected to VirtualHere - CTS value follow the RTS value.
############

$ /usr/local/bin/python
Python 2.7.16 (default, Oct 10 2019, 22:02:15)
[GCC 8.3.0] on linux2
Type "help", "copyright", "credits" or "license" for more information.
>>> import serial
>>> import time
>>> s = serial.Serial('/dev/ttyUSB0',9600)
>>> s.getCTS()
True
>>> s.setRTS(True)
>>> s.setRTS(False)
>>> s.setRTS(True)
>>> time.sleep(0.05)
>>> s.getCTS()
True
>>> s.setRTS(False)
>>> time.sleep(0.05)
>>> s.getCTS()
False
>>> s.write('hello')
5
>>> s.read()
'h'
>>> s.read()
'e'
>>> exit()